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MetaCyc Reaction: 2.1.1.72

Superclasses: Reactions-Classified-By-Conversion-Type Simple-Reactions Chemical-Reactions
Reactions-Classified-By-Substrate Macromolecule-Reactions Polynucleotide-Reactions DNA-Reactions

EC Number: 2.1.1.72

Enzymes and Genes:
DNA adenine methyltransferase Inferred from experiment : yhdJ ( Escherichia coli K-12 substr. MG1655 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: site-specific DNA-methyltransferase (adenine-specific)

Enzyme Commission Synonyms: modification methylase, restriction-modification system

Standard Gibbs Free Energy (ΔrG in kcal/mol): -34.74228 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is a large group of enzymes, most of which, with enzymes of similar site specificity listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease), form so-called ’restriction-modification systems’. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html.

Citations: [Yuan81, Roberts90, Kessler90]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02961

Relationship Links: BRENDA:EC:2.1.1.72 , ENZYME:EC:2.1.1.72 , IUBMB-ExplorEnz:EC:2.1.1.72 , UniProt:RELATED-TO:O41063 , UniProt:RELATED-TO:P00472 , UniProt:RELATED-TO:P00473 , UniProt:RELATED-TO:P00474 , UniProt:RELATED-TO:P04043 , UniProt:RELATED-TO:P04392 , UniProt:RELATED-TO:P04393 , UniProt:RELATED-TO:P08957 , UniProt:RELATED-TO:P0AEE8 , UniProt:RELATED-TO:P12427 , UniProt:RELATED-TO:P14385 , UniProt:RELATED-TO:P14751 , UniProt:RELATED-TO:P14827 , UniProt:RELATED-TO:P21311 , UniProt:RELATED-TO:P24582 , UniProt:RELATED-TO:P25238 , UniProt:RELATED-TO:P25239 , UniProt:RELATED-TO:P25240 , UniProt:RELATED-TO:P29538 , UniProt:RELATED-TO:P29749 , UniProt:RELATED-TO:P31118 , UniProt:RELATED-TO:P33563 , UniProt:RELATED-TO:P35516 , UniProt:RELATED-TO:P43422 , UniProt:RELATED-TO:P43641 , UniProt:RELATED-TO:P44414 , UniProt:RELATED-TO:P44431 , UniProt:RELATED-TO:P45454 , UniProt:RELATED-TO:P50193 , UniProt:RELATED-TO:P73682 , UniProt:RELATED-TO:P95510 , UniProt:RELATED-TO:Q7B7V5 , UniProt:RELATED-TO:Q9PIS1 , UniProt:RELATED-TO:Q03055 , UniProt:RELATED-TO:Q47911 , UniProt:RELATED-TO:Q51829 , UniProt:RELATED-TO:Q56004 , UniProt:RELATED-TO:Q57168


References

Kessler90: Kessler C, Manta V (1990). "Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3)." Gene 92(1-2);1-248. PMID: 2172084

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Roberts90: Roberts RJ (1990). "Restriction enzymes and their isoschizomers." Nucleic Acids Res 18 Suppl;2331-65. PMID: 2159140

Yuan81: Yuan R (1981). "Structure and mechanism of multifunctional restriction endonucleases." Annu Rev Biochem 50;285-319. PMID: 6267988


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 38:D473-D479 2010
Page generated by SRI International Pathway Tools version 18.0 on Wed Aug 27, 2014, biocyc14.